Two first ladies have been active politicians: Martha Sahagún, who married
Vicente Fox during his tenure (2001–2006), had been a party activist and candidate for mayor of
Celaya on the PAN party ticket, and was briefly considered a contender for PAN's nomination to run for either the Jefe de Gobierno (Governor of the Federal District) or president in the 2006 election.
Margarita Zavala, wife of
Felipe Calderón, was a deputy from 2003 to 2006. In the
2018 Mexican general election, she was a pre-candidate for the nomination of PAN, and then she briefly ran as an independent.
Beatriz Gutiérrez Müller (2018 to 2024), wife of Andrés Manuel López Obrador, abstained from using the title of first lady. She stated it was a "role with no concrete functions or responsibilities." She also said she wanted to "serve Mexico any way she can", and that the title "first lady" is "somewhat classist". Gutiérrez Müller also refused the position as head of the National DIF. == List of first ladies and gentlemen of Mexico ==