The protein encoded by this gene is a member of the
immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. This encoded protein is a
cis-trans prolyl isomerase that binds the immunosuppressants FK506 (
tacrolimus) and rapamycin (
sirolimus). It is highly similar to the
FK506-binding protein 1A. Its physiological role is thought to be in
excitation-contraction coupling in
cardiac muscle. There are two alternatively spliced transcript variants of this gene encoding different isoforms. == Clinical significance ==