FKBPL has similarity to the
immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein
folding and
trafficking. The encoded protein is thought to have a potential role in the induced
radioresistance. Also it appears to have some involvement in the control of the
cell cycle. FKBPL is involved in cellular response to stress. It was first isolated in 1999 and was initially named
DIR1. It was later reclassified because of its
homology to the
FKBP family of proteins and was renamed
FKBP-like (FKBPL). A separate study that found it to be involved in the stabilisation of newly synthesised
p21 termed it
Wisp39. It is known to interact with
Hsp90,
glucocorticoid receptor and
dynamitin and may play a role in signalling, like other
FKBPs. FKBPL has also been shown to influence
estrogen receptor signalling and can have a determinant effect on response to the breast cancer drug
tamoxifen. ==References==