Mophosho was born in 1921 in
Alexandra, a
township outside
Johannesburg in the former
Transvaal. Her father was chronically ill and her mother, though trained as a teacher, worked as a domestic worker. The eldest of three siblings, Mophosho left school at Standard Six to enter the workforce, first as a domestic worker and then as a worker in a garment factory. She joined the
African National Congress (ANC) in 1952, inspired by the party's
Defiance Campaign of that year. She became involved in organising the ANC's next major campaign, the 1955
Congress of the People; she travelled Alexandra soliciting residents' proposals for the
Freedom Charter. She also joined the
ANC Women's League and was a member of the executive of the
Federation of South African Women; in that capacity, she helped organise the national
Women's March of 1956. The following year, she was a member of the committee that organised the
Alexandra bus boycott. Later described by
Maggie Resha as "a magic organiser", Mophosho ultimately became a full-time organiser for the ANC. She was arrested in 1958 during a women's anti-
dompas protest in Johannesburg. == Activism in exile ==