MarketFluticasone propionate
Company Profile

Fluticasone propionate

Fluticasone propionate, sold under the brand names Flovent and Flonase among others, is a glucocorticoid steroid medication. When inhaled it is used for the long term management of asthma and chronic obstructive pulmonary disease (COPD). In the nose it is used for hay fever and nasal polyps. It can also be used for mouth ulcers.

Medical uses
Fluticasone propionate is used by powder or aerosol inhalation for the prophylaxis of asthma. ==Adverse effects==
Adverse effects
The nasal spray and oral inhaler formulation have fewer corticosteroid side effects than the tablet formulation because they limit systemic (blood) absorption. However, systemic absorption is not negligible even with correct administration. These side effects include weakened immune system, increased risk of systemic infections, osteoporosis, and elevated pressure in the eyes. Nasal spray Common side effects may include nasal irritation (burning, stinging, bleeding), headache, upset stomach (nausea, vomiting), and diarrhea. Rare side effects include infection (evidenced by, for example, fever, sore throat, and cough), vision problems, severe swelling, hoarse voice, and difficulty breathing or swallowing. ==Pharmacology==
Pharmacology
Fluticasone propionate is a highly selective agonist at the glucocorticoid receptor with negligible activity at androgen, estrogen, or mineralocorticoid receptors, ==Interactions==
Interactions
Fluticasone propionate is broken down by CYP3A4 (cytochrome P450 3A4), and has been shown to interact with strong CYP3A4 inhibitors such as ritonavir and ketoconazole. Ketoconazole, an antifungal drug, has been shown to increase fluticasone concentration leading to systemic corticosteroid side effects. == Society and culture ==
Society and culture
In 2024, GSK plc removed Flovent from the market and replaced it with an authorized generic. ==References==
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