On 31 May 1727 at the age of 16 Sydenham matriculated at
Wadham College, Oxford. In 1613 his great-grandfather Rev.
Humphry II Sydenham (1591–1650), "Silver-Tongue Sydenham", of Combe, Dulverton, had become a Fellow of the newly founded Wadham College, founded posthumously by his fellow Somerset resident
Nicholas II Wadham (1531–1609) and his wife. Humphry II Sydenham was the first to graduate as
Master of Arts from that foundation on 3 December 1613. Floyer Sydenham gained his B.A. at Wadham College in 1731 and M.A. in 1734. In 1735 he was a
barrister-at-law in
Lincoln's Inn. He was a
Fellow and sometime
Moderator of Philosophy at Wadham College, and was later
Rector of
Esher until 1744. ==Literary works==