The parish is multi-lingual, with Masses said in English daily, Urdu weekly, and Punjabi, Tamil and Konkani on special feasts. In 2011, the parish is estimated to provide spiritual care to 15,000 people largely due to inter-parish migration and the construction of many housing units in the vicinity of the Church. The territory includes the affluent areas of Clifton and the Defence Housing Society. In Feb. 2011 the parish included about 1,250 English- and about 1,600 Urdu-speaking families. Over the years the following groups have functioned in the parish, Parish Council, Senior, Junior and Children's Choirs (English and Urdu), Legion of Mary ( several presidia),
Vincent de Paul Society, Youth group (English and Urdu), Lectors’ group (English and Urdu), Eucharistic Ministers, Ushers and Collectors, Family of Jesus and Mary, Familia group, Sunday school (English and Urdu) and Security group. The parish also has chapters of the Catholic Women's Guild, Women's Sodality and the Goinkars’ Own Academy. The old St. Anthony's School, built along the wall of the compound was demolished and in its place, on the opposite side, an imposing three storied structure was constructed for the school which incorporated a hall to seat the overflow of parishioners from the church in 1990. Every Tuesday, a large number of devotees from all over Karachi make the pilgrimage to the church to attend the special prayers to St. Anthony. So also, a large number of the faithful attend the Tridensina prayers which culminate in the Feast of the patron on June 13. The Novena to Our Lady of Valankani in September is also heavily attended by people from all over Karachi. The Fete after the Patron's Feast draws large crowds and affords an opportunity to the parishioners not only to socialise, but also raises funds for the charitable undertakings of the parish. The parish also caters to the needs of new communities and Masses are said in the newly constructed premises of the Presbytery (in Civil Lines), Stella Maris (old Clifton) and Shirin Jinnah Colony (near the Boating Basin). The parish is also home to a number of religious communities such as the
Congregation of Jesus and Mary,
Sisters of the Good Shepherd and the
Daughters of the Cross. The parish also fields a soccer team and participated in the Karachi Goan Association Gymkhana All-Christian football tournament on 23 November 2003 at the KGA ground. The inaugural match was played between
St. Lawrence's Parish and St. Anthony's Parish. St Anthony's Church has made it onto the
Sindh government's new list of 1,016 buildings to be classified as heritage listed. On 25 March 2012, more than 600 people gathered at the Church for a special Mass to celebrate Sister
John Berchmans Conway and Fr.
Robert McCulloch receiving the country's highest civilian award - Sitara-e-Quaid-e-Azam, for their services in the fields of education, health and promoting interfaith harmony. In 2012, as part of its 75th anniversary celebrations, the parish has started a free medical care program for the poor. On 5 October 2019 the Archbishop announced that Fr. Arthur Charles would be the new parish priest of the Parish. ==Famous parishioners==