Córdova worked at the Space Astronomy and Astrophysics Group at the
Los Alamos National Laboratory from 1979 to 1989, where she also served as Deputy Group Leader. She headed the Department of Astronomy and Astrophysics at
Pennsylvania State University from 1989 to 1993. In 1993, NASA Administrator Daniel Goldin appointed Córdova
NASA Chief Scientist, the first woman to serve in the role. Within her role as Chief Scientist, Córdova connected the gap between NASA and the goals of the larger scientific community, especially through the International Space Station Córdova then went to the
University of California, Santa Barbara where she was Vice-Chancellor for Research and a Professor of Physics. In 2002 she was appointed
Chancellor of the
University of California, Riverside by UC President Richard C. Atkinson, where she was also a Distinguished Professor of Physics and Astronomy. Córdova led the initial steps toward establishing the
UC Riverside School of Medicine. Córdova became the eleventh president of
Purdue University in 2007 and promoted student success and the commercialization of interdisciplinary research. She is the first and only woman to serve in this role. Her administration oversaw the establishment of Purdue's
College of Health and Human Sciences and its Global Policy Research Institute. At the end of her term, Purdue's trustees credited her with leading the school to record levels of research funding, reputational rankings, and student retention rates. Córdova's scientific career contributions have been in the areas of observational and experimental
astrophysics, multi-spectral research on
x-ray and
gamma ray sources, and space-borne instrumentation. She has published more than 150 scientific papers and numerous science policy papers. In September 2007, she was appointed to the board of directors of BioCrossroads,
Indiana's initiative to grow the
life sciences through a public-private collaboration that supports the region's research and corporate strengths while encouraging new
business development. Córdova was appointed by President
George W. Bush to the
National Science Board in 2008. President
Barack Obama appointed Córdova to the Board of Regents of the
Smithsonian Institution in 2009, and she served until 2014. She was chair of the Board of Regents from 2012 to 2014. In 2014, Córdova was nominated by Obama and confirmed by the
United States Senate as the 14th head of the
National Science Foundation. At the conclusion of her term at NSF in 2020, Córdova was elected to the Caltech Board of Trustees and named as an External Science Advisor to the Science Philanthropy Alliance. In May 2021, she was named President of the Science Philanthropy Alliance. ==Personal life==