At an unspecified date, Campana left Colle di Val d'Elsa for Florence, where he came into contact with the powerful
Medici family. By 1516, he had secured their protection and entered their service. His rise was swift, as evidenced by his commission on December 22, 1516, to find a workshop for
Michelangelo to work on marble. During this period, Campana served
Lorenzo de' Medici, Duke of Urbino, and learned the trade of secretary and political advisor from Goro Gheri. Campana later entered the service of Cardinal Giulio de' Medici and continued as his chamberlain even after Giulio ascended to the papal throne as
Clement VII in 1523. On the occasion of the pope's election, Campana delivered a panegyric oration in honor of the late
Adrian VI.
Under Clement VII On 12 December 1528, Clement VII sent Campana on a delicate mission to the English court to destroy a secret
papal bull that annulled Henry VIII's marriage to Catherine of Aragon. Henry VIII had requested the annulment, and
Cardinal Campeggio had been tasked with examining the issue. The bull granted the divorce but was to be shown only to Henry and
Cardinal Wolsey privately. However, the situation shifted after the
Siege of Naples in 1528, and the pope, now allied with Emperor
Charles V, no longer needed English support. Campana's mission was to destroy the bull, all while pretending his journey was part of a diplomatic effort to resolve the marriage issue. Campana met
Francis I on the road on 1 January 1529. After stopping in Paris, Campana reached the English court on 17 January, where he was received with many honors because he was believed to be there to favorably resolve the divorce issue. He met with Henry VIII and Wolsey, but had a great argument with Henry on 19 May. Eventually, the bull was destroyed, allowing Campana to return to Florence on May 26, 1529.
Under Alessandro de Medici In 1530, Clement VII directed Campana to serve the newly established
Duchy of Florentine Republic and assist
Alessandro de' Medici, who was destined to become the head of the government. According to
Benedetto Varchi, as the Republic's first secretary during
Simone Tornabuoni’s
gonfalonierate, Campana altered public records to favor Alessandro's rise. On May 1, 1531, he was appointed first chancellor of the Republic, and in July, he read the decree of Charles V, proclaiming Alessandro de' Medici as the head of Florence. He stayed by Alessandro's side, serving as his trusted advisor and secretary until the duke's demise. Campana played a crucial role in balancing the influence of aristocratic advisors like Matteo Strozzi,
Francesco Vettori, and Roberto Acciaiuoli, and significantly shaped all of the new duke's political endeavors. Detailed records from this period are scarce; it is only known that on January 3, 1536, he accompanied the duke to
Naples, where Alessandro had to defend himself before Charles V against accusations leveled by Florentine exiles. Campana enjoyed numerous benefits: in 1535, he received a
canonry in the cathedral. He later acquired the parish of
Cavriglia in
Valdarno, the Church of San Romolo in Florence, the chapel of the Abbey of
Dovadola, the priory of Montughi, the parish of Miransù, the Church of Montui, and the priory of Sant'Antonio in Fano. Despite Lastri's belief that Campana had taken ecclesiastical orders due to his work with the pope, it appears certain that he remained a layman throughout his life. On January 6, 1537, he was among the first, alongside
Cardinal Cybo (cousin of Clement VII), to be informed of Alessandro's assassination. Together, they made swift decisions: to discreetly move the duke's body to
San Lorenzo, immediately contact
Alessandro Vitelli, the commander of the imperial troops, urging him to arrive quickly with as many soldiers as possible, and to keep the news quiet to allow the day to pass peacefully. In the aftermath, he aligned himself with Cybo, Vitelli, and Maurizio Albertoni, who were strong supporters of imperial policies. They believed in the presence of Spanish soldiers and wanted to reinforce Charles V's control over the city, advocating for the election of
Giulio, Alessandro's illegitimate son, who was still a child. However, the group of aristocrats led by Vettori and
Francesco Guicciardini succeeded in electing
Cosimo, the son of
Giovanni dalle Bande Nere, with the goal of liberating Florence from imperial influence. This was a setback for Campana and explains (along with the belief that the new ruler's position was precarious) his initial reluctance towards Cosimo. When asked to write a letter of reconciliation to Cardinals
Salviati,
Ridolfi, and
Gaddi, who were leaders of the Medici opposition, he declined, using illness as an excuse. However, he soon changed his stance and didn't hesitate to mislead Bernardo Giusti, his rival, persuading him to resign from serving the new prince to ensure his own confirmation as first secretary, a position he dedicated himself to wholeheartedly. His work in these challenging early years of government proved crucial for Cosimo. Thanks to Campana and other trusted advisors (
Lelio Torelli, Pierfrancesco Ricci, Angelo Marzi, Ugolino Grifoni, Lorenzo Pagni), Cosimo had a reliable core that solidified the foundation of his fragile power.
Under Cosimo I Guided by Campana's counsel, Cosimo immediately adopted a two-pronged strategy: internally, he asserted his power with a firm, absolutist approach, consolidating his control within Florence. Externally, he sought to gradually wrest autonomy from Charles V, reducing the Holy Roman Emperor's influence over the Medici principality. This approach was evident in the May 1537 negotiations with the imperial ambassador, Ferdinando da Silva, Count of Cifuentes. Campana advised Cosimo to demand the same level of authority Alessandro had held before his death and the return of the fortresses in Florence,
Livorno, and
Pisa, which were still under Spanish control and hindered the Medici principality's independence. A staunch opponent of the new pope,
Paul III, Campana also encouraged Cosimo to adopt a hostile stance towards him, leading Cosimo to reject a marriage proposal with the pope's relative,
Vittoria Farnese, in January 1537. The following year, Campana and Cybo were dispatched to the
Nice conference to address unresolved Tuscan matters with the emperor, such as the return of the fortresses and the proposed marriage between Cosimo and
Margaret of Austria. Campana met with Cybo in Massa in late April and then traveled by sea from
La Spezia to
Genoa and Nice, arriving on May 10. During the talks, he presented the Florentine government's perspective to Charles V. In August of the same year, the pope accused Campana before imperial ministers of intrigues, arrogance, and boasting against the emperor. However, Cosimo fervently defended Campana, proving all the accusations to be false. This only intensified Campana's hatred toward Paul III. In the following years, he not only stirred his lord but also the Tuscan clergy against the pope, going so far as to call him "evil, arrogant, unjust, and shameless," and declaring, "I do not care about dying, as long as I do not do it before Pope Paul!" In October, new accusations were leveled against Campana by Don Giovanni de Luna, commander of the Spanish garrison in Florence, who sought to discredit Cosimo before the emperor through Campana. Once again, the slander was not believed. Campana's work regarding internal politics in 1538-39 was particularly significant. He successfully marginalized Cardinal Cybo, who, in his attempts to expand his influence and power, had kept Giulio, Alessandro's illegitimate son and potential rival to Cosimo, by his side. In 1540, Campana intervened in the dispute over the collection of extraordinary tithes imposed on all Italian ecclesiastical benefices by the pope. Together with Torelli, he introduced a ban suspending all payments until an agreement with the pope was reached. In August 1541, he accompanied the duke to Genoa to pay homage to the emperor. == Later years ==