Di Mariano started playing football in Palermo, then at the age of 13 he left for
Lecce. He made his professional debut with Lecce on 9 September 2012 against
Cuneo in the
Lega Pro Prima Divisione. Following spells at
Ancona and
Monopoli on loan from
Roma, Di Mariano joined
Novara on 20 July 2016. On 29 January 2020, he joined
Juve Stabia on loan with an obligation to buy. He successively returned to Lecce, being part of the squad that won promotion to Serie A by the end of the
2021–22 Serie B campaign. On 16 August 2022, Lecce announced Di Mariano had been transferred to his hometown club
Palermo, signing a three-year contract for the
Rosanero. After three years with Palermo, on 23 July 2025 Di Mariano left for
Modena, signing a two-year deal with the
Canarini. On 31 January 2026, Di Marino moved to
Padova on a two-and-a-half-season deal. ==Personal life==