A member of the
Orsini family, Franciotto Orsini was born in
Rome in 1473, the son of Orso Orsini di Monterotondo and Costanza
Savelli. He was a cousin of
Pope Leo X on his father's side. in succession to Cardinal
Ippolito d'Este, who had died on 3 September 1520; Orsini held the post until 1530, when he was succeeded by Cardinal Francesco Corsaro. On 18 January 1519 he was named administrator of the
see of Boiano, holding this post until 24 July 1523. He was deposed from the cardinalate on 8 August 1519, though later reinstated. Sometime after 1519, he opted for the deaconry of
Santa Maria in Cosmedin. He participated in both the
papal conclave of 1521-22 that elected
Pope Adrian VI, and in the
papal conclave of 1523 that elected
Pope Clement VII. On 15 June 1524 he became administrator of the
see of Fréjus, holding this post until 15 December 1525. He was the administrator of the
see of Rimini from 23 March 1528 until 7 April 1529. == Family ==