Francisco married Queen
Isabella II of Spain, his
double first cousin, on 10 October 1846. There is evidence that Isabella would rather have married his younger brother,
Infante Enrique, Duke of Seville, and complained bitterly about her husband's effeminate habits after their first night together. Twelve children were born during the marriage: • Infante Luis Fernando of Spain (20 May 1849) stillbirth. • Infante Fernando Francisco of Spain (12 July 1850), died five minutes after birth. •
Infanta María Isabel of Spain (1851–1931): married her mother's and father's first cousin
Prince Gaetan, Count of Girgenti. • Infanta Maria Cristina of Spain (5 January 1854 – 7 January 1854). • Infanta Margarita of Spain (23 September 1855 – 24 September 1855), born prematurely. • Infante Francisco de Asis Fernando of Spain (21 December 1856), stillbirth. •
Alfonso XII of Spain (1857–1885) Future King of
Spain. • Infanta Maria de la Conception of Spain (1859 – 21 October 1861). •
Infanta María del Pilar of Spain (1861–1879). •
Infanta María de la Paz of Spain (1862–1946); married her paternal first cousin
Prince Louis Ferdinand of Bavaria. •
Infanta Eulalia of Spain (1864–1958); married her maternal first cousin
Infante Antonio d'Orléans, Duke of Galliera. • Infante Francisco de Asis Leopoldo Maria Enrique of Spain (24 January 1866 – 14 February 1866). There has been considerable speculation that not all, if any, of Isabella's children were fathered by Francisco de Asís; this has been bolstered by rumours that he was either
homosexual or impotent. Francisco recognised all of them: however, he acted aggrieved and proceeded to blackmail the queen to receive money in exchange for keeping silent. The extortion by her husband would continue and intensify during Isabella's exile. ==Later life==