•
Apolinario de la Cruz (1815–1841), Filipino religious leader •
Bethania de la Cruz (born 1987), Dominican volleyball player •
Bryan De La Cruz (born 1996), Dominican baseball player •
Cacho de la Cruz (1937–2025), Argentine-Uruguayan entertainer •
Carlos de la Cruz, Cuban-American chairman of CC1 Companies •
Claudia De la Cruz (born 1980/1981), American community organizer and activist •
David de la Cruz (born 1989), Spanish cyclist •
Elly De La Cruz (born 2002), Dominican baseball player •
Eulogio de la Cruz (1984–2021), Dominican baseball player •
Fernando de la Cruz (born 1971), Dominican baseball player •
Francisco Dela Cruz (1962–2019), Northern Mariana Islands politician •
Jerry De La Cruz (born 1948), American artist •
Jessica de la Cruz (born 1981), American politician •
José María de la Cruz (1799–1875), Chilean general and politician •
José de la Cruz (1746–1829), Filipino writer more popularly known as Huseng Sisiw •
Joshua Dela Cruz (born 1989), Filipino-American actor •
Juan de la Cruz (1542–1591), Spanish friar and poet •
Juan de la Cruz (basketball) (born 1954), Argentine-born Spanish pivot •
Juana Inés de la Cruz (1648–1695), Mexican scholar, poet, and nun •
Magdalena de la Cruz (1487–1560), Spanish Franciscan nun of Cordova •
Maximiliano de la Cruz (born 1976), Uruguayan actor and television presenter •
Melissa de la Cruz (born 1971), American author •
Monica De La Cruz (born 1974), American politician •
Nicolás de la Cruz (born 1997), Uruguayan footballer •
Oswaldo de la Cruz (1940–2021), Peruvian politician •
Ramón de la Cruz (1731–1794), Spanish neoclassical dramatist •
Tommy de la Cruz (1911–1958), Dominican baseball player •
Ulises de la Cruz (born 1974), Ecuadorian footballer •
Veronica De La Cruz (born 1980), Filipino-American television anchor •
Virginia de la Cruz, Argentine-Paraguayan actress ==Fictional characters==