In his
Quod nihil scitur (
That Nothing Is Known), written in 1576 and published in 1581, he used the classical skeptical arguments to show that
science, in the
Aristotelian sense of giving necessary reasons or causes for the behavior of nature, cannot be attained: the search for causes quickly descends into an infinite regress and so cannot give certitude. He also attacked demonstrations in the forms of
syllogisms, arguing that the particular (the conclusion) is needed to have a conception of the general (the premises) and thus that syllogisms were circular and did not add to knowledge. . Perfect knowledge, if attainable, is the intuitive apprehension of each individual thing. But, he then argued, even his own notion of science (perfect
knowledge of an individual thing) is beyond human capabilities because of the nature of objects and the nature of man. The interrelation of objects, their unlimited number, and their ever-changing character prevent their being known. The limitations and variability of man's senses restrict him to knowledge of appearances — the real substances cannot be known. In forming this last argument he drew on his experience of Medicine to show how unreliable our
sense experience is. Sanches' first conclusion was the usual fideistic one of the time, that truth can be gained by faith. His second conclusion was to play an important role in later thought: just because nothing can be known in an ultimate sense, we should not abandon all attempts at knowledge but should try to gain what knowledge we can, namely, limited, imperfect knowledge of some of those things with which we become acquainted through observation, experience, and judgment. The realization that
nihil scitur ("nothing is known") thus can yield some constructive results. This early formulation of "constructive" or "mitigated" skepticism was to be developed into an important explication of the new science by
Marin Mersenne,
Pierre Gassendi, and the leaders of the
Royal Society. ,
Franciscus Sanches Bracharensis, or Francisco Sanches of Braga. From the statue by Salvador Barata Feyo. == Works ==