Schedule Game summaries Week 1: at Seattle Seahawks With their fourth straight win in Seattle, the 49ers started 1–0 for the third consecutive season.
Week 2: at New Orleans Saints Week 3: vs. Arizona Cardinals 49ers kicker
Eddy Piñeiro made a game-winning 35-yard field goal as time expired, giving the 49ers a 16–15 victory. Despite the win, it was later revealed that defensive end
Nick Bosa would miss the remainder of the season after suffering a torn ACL in his right knee.
Week 4: vs. Jacksonville Jaguars The 49ers lost to the Jaguars for the first time since the
2005 season and recorded their first-ever home loss to them. Following the game, Jaguars coach
Liam Coen and 49ers defensive coordinator
Robert Saleh had to be separated during a heated postgame exchange, after Saleh made a remark earlier in the week about the Jaguars 'legally stealing signals.'
Week 5: at Los Angeles Rams With the hard fought win, the 49ers improve to 4–1 while securing their first win over the Rams since Week 2 of 2023, snapping a three-game losing streak to them.
Week 6: at Tampa Bay Buccaneers With the loss, the 49ers fell to 4–2. Following the game, it was revealed that linebacker
Fred Warner would miss the remainder of the season after suffering a dislocated and broken ankle midway through the game.
Week 7: vs. Atlanta Falcons The 49ers rebounded from their loss to Tampa Bay to improve to 5–2 overall and 2–1 against the NFC South.
Week 8: at Houston Texans The 49ers faced off against Texans' head coach
DeMeco Ryans, who served on San Francisco’s coaching staff from 2017 to 2022. The 49ers ended an NFL-record streak of 14 consecutive games without an interception, spanning 469 pass attempts, when cornerback
Deommodore Lenoir intercepted Texans quarterback
C. J. Stroud on the final play of the first half. The 49ers also finished with 10 rushing attempts, setting a franchise-low record. With their first loss to Houston since
2009, the 49ers dropped to 5–3 and 0–2 against the AFC South.
Week 9: at New York Giants With the win, the 49ers matched their win total from 2024 and improved to 6–3.
Week 10: vs. Los Angeles Rams With their fourth loss in their last five games against the Rams, the 49ers fell to 6–4.
Week 11: at Arizona Cardinals Brock Purdy made his return after suffering a toe injury on September 28 against the Jacksonville Jaguars. Although the 49ers were outgained by more than 200 yards, they still dominated the Cardinals. With the victory, San Francisco surpassed its win total from the previous season.
Week 12: vs. Carolina Panthers Running back
Christian McCaffrey faced his former team, the Carolina Panthers, whom he played for from 2017 to 2022, for the first time since being traded during the 2022 season. McCaffrey recorded 142 yards from scrimmage and a touchdown, helping the 49ers overcome three first-half interceptions by Purdy to secure the win. Late in the game, Panthers safety
Tre'von Moehrig struck
Jauan Jennings in the groin following a run play. After the game, Jennings responded by punching Moehrig in the helmet. The NFL subsequently suspended Moehrig for one game without pay, while Jennings was fined $12,172 for his actions. With the win, the 49ers finished 3–1 against the NFC South.
Week 13: at Cleveland Browns With another dominant win, the 49ers improved to 9–4 entering their bye. This was also their first victory in Cleveland since
1984.
Week 15: vs. Tennessee Titans With the win, the 49ers improved to 10–4 and 1–2 against the AFC South.
Week 16: at Indianapolis Colts Earlier in the afternoon slate of games, the
Lions' loss to the
Steelers meant the 49ers clinched a playoff berth. The 49ers' offense dominated the Colts' defense. Brock Purdy completed 25-of-34 passes for 295 yards as San Francisco totaled 440 yards of offense. Christian McCaffrey rushed 21 times for 117 yards and added six receptions for 29 yards and two touchdowns. George Kittle recorded seven receptions for 115 yards and one touchdown, and the team did not punt at any point during the blowout win against the Colts. It was the first time the 49ers beat the Colts since
2001. With the win, the 49ers finished 2–2 against the AFC South (3–2 against the AFC) and 7–2 on the road.
Week 17: vs. Chicago Bears The Bears and 49ers engaged in a shootout, with the game decided on the final play when Bears quarterback
Caleb Williams’ last-ditch pass to wide receiver
Jahdae Walker fell incomplete in the end zone from San Francisco’s 2-yard line, sealing the 49ers’ victory. With the win, the 49ers improved to 12–4 (8–2 against the NFC), putting them one win away from clinching the NFC West title and the NFC's No. 1 seed.
Week 18: vs. Seattle Seahawks The 49ers' high-powered offense was stuffed by the Seahawks defense, being limited to 173 total yards, their fewest in any regular-season game under head coach Kyle Shanahan. With the loss, the 49ers dropped to 12–5, finishing 9–3 against the NFC (4–2 against the NFC West), and 5–3 at home. They were also denied the division title and the NFC's #1 seed. With the
Rams defeating the
Cardinals the following day, the 49ers fell to the sixth seed and were scheduled to face the
Eagles in the Wild Card Round.
Standings Division Conference ==Postseason==