In September 2020, Agamenone switched his tennis country of allegiance from Argentina to Italy. Having never previously won a match at ATP Challenger level, Agamenone won the event in Prague in 2021, defeating
Ryan Peniston in the final. The success took his ranking inside the top 300 for the first time. The following month, he repeated the feat, defeating
Sebastián Báez to win in Kyiv. In 2022, Agamenone's reached the semifinal at the ATP Challenger in
Bendigo (l.
Enzo Couacaud), pushed him into the top 200 for the first time. He made his Grand Slam debut when he entered the
2022 French Open main draw as a lucky loser. He was defeated in the first round by
Mackenzie McDonald. As a result, he reached the top 150 at World No. 148 on 6 July 2022. He qualified for the
2022 Croatia Open Umag making his ATP debut and reached the quarterfinals defeating
Laslo Djere for his first ATP win and fourth seed and world No. 32 Sebastián Báez. Next he defeated
Marco Cecchinato to reach the first ATP semifinal of his career. As a result, he moved close to 30 positions in the rankings in the top 110 at No. 108 on 1 August 2022. ==Challenger and Futures finals==