Following his graduation from
Harvard University, Cotton began teaching at
Massachusetts Institute of Technology (MIT). In 1961, at 31-years-old, he became the youngest person to have received a full professorship at MIT. and in 1964 identified the
quadruple bond in the Potassium octachlorodirhenate| ion. His work soon focused on other metal-metal bonded species, elucidating the structure of chromium(II) acetate. He was an early proponent of single crystal
X-ray diffraction as a tool for elucidating the extensive chemistry of metal complexes. Through his studies on clusters, he demonstrated that many exhibited "
fluxionality", whereby ligands interchange coordination sites on spectroscopically observable time-scales. He coined the term "
hapticity" and the nomenclature that derives from it. In 1962 he undertook the crystal structure of the Staphylococcal nuclease enzyme, solved to 2Å resolution in 1969, published in 1971, and deposited in the
Protein Data Bank (PDB code 1SNS) as one of the first dozen protein crystal structures. In 1972 Cotton moved to Texas A&M University as the Robert A. Welch Professor of Chemistry. The following year he was named the Doherty-Welch Distinguished Professor of Chemistry. He also served as the director of the university's Laboratory for Molecular Structure and Bonding. ==Pedagogical influence==