During his career in the computer and software industries, Moss served as CEO and chairman of
Tivoli Systems Inc., a pioneer in the distributed systems management field, which he took public in 1995 and subsequently merged with IBM in 1996. Tivoli was a venture-backed startup that successfully competed with larger companies to redefine and standardize the technology behind network and systems management. The acquisition by IBM became more of a “reverse merger,” in that Tivoli became the network and systems management division of IBM and one of its largest software businesses, growing to several billion dollars. Moss became the general manager of the Tivoli business at IBM; he retired from Tivoli as chairman in 1998. He also co-founded several other companies, including Stellar Computer, Inc., a developer of graphic supercomputers; and Bowstreet, Inc., a pioneer in the emerging field of Web services that was acquired by IBM and where he was chairman. Moss also served on the advisory board of
nLayers Inc., which was later acquired by
EMC. In 2009,he co-founded and was a director of Bluefin Labs, which uses machine learning technology to provide brands, agencies and media companies with real-time TV audience response insights through social media analysis. Bluefin was sold to
Twitter in 2013 for a reported $100 Million. Beginning in the early 2000’s, Moss has sought to apply his experience in business and information technology to the life sciences. His 2011 New York Times opinion piece “Our High-Tech Health-Care Future” foreshadowed the emergence of the digital health industry. He co-founded and was on the board of Infinity Pharmaceuticals, Inc., an early-stage cancer-drug discovery company doing innovative work at the intersection of technology and the life sciences; he retired from Infinity's board in 2011. In addition, he chaired the advisory council for the creation of the
Systems Biology Department at
Harvard Medical School. He also served as an advisor to a number of startups that pioneered new ways to improve human health by giving people more control over their own health. These include ginger.io (merged with Headspace Health), Maxwell Health (acquired by Sun Life Financial) and Audax Health (acquired by Optum). In 2012, Moss co-founded and became chairman of Twine Health, which was a spinoff of research performed by his doctoral student and co-founder Dr. John Moore in his New Media Medicine group at the MIT Media Lab. Twine was an early innovator in digital healthcare and provided a platform to enable patients to achieve maximal self-efficacy in managing their chronic conditions in continuous collaboration with their care team. Twine was acquired by FitBit in 2018. From 2016 to 2019, Moss served as director and strategic advisor to Humatics Inc., a provider of micro-location systems for navigation for robotics and industrial automation. ==Academic career==