The
Detroit Lions selected Ragnow in the first round (20th overall) of the
2018 NFL draft. Ragnow was the first center drafted in 2018 and was the second interior lineman drafted. Ragnow became the highest drafted center from Arkansas, surpassing
Steve Korte who was selected 38th overall during the
1983 NFL draft. On May 12, 2018, the Lions signed Ragnow to a four-year, $11.78 million contract that includes $9.21 million guaranteed and a
signing bonus of $6.64 million. The Lions immediately moved Ragnow to offensive guard although he had been used chiefly as a center during his collegiate career. The Lions had
Graham Glasgow slated to be the starting center after the departure of
Travis Swanson. Head coach
Matt Patricia named Ragnow the starting left guard to begin the regular season. He started alongside offensive tackles
Taylor Decker,
Rick Wagner, right guard
T. J. Lang, and center Graham Glasgow. He made his professional regular season debut and first career start during the Lions' season-opening 48–17 loss to the
New York Jets. He finished the season starting all 16 games at left guard. On December 21, 2020, he was named to the
2021 Pro Bowl. On April 28, 2021, the Lions exercised the fifth-year option on Ragnow's contract. He signed a four-year contract extension worth $54 million with the Lions on May 7. On October 6, 2021, Ragnow was placed on
injured reserve with a toe injury. He started in four games on the year. In the 2022 season, Ragnow started in 16 games. In the 2023 season, Ragnow started in 15 regular season games and all three of the Lions' postseason games. In the 2024 season, Ragnow started in 16 regular season games and the Lions' one postseason game. On June 2, 2025, Ragnow posted a farewell post onto his Instagram which announced his retirement after seven seasons in the NFL. On November 26, 2025, Ragnow announced that he was coming out of retirement to rejoin the Lions. Three days later, however, Ragnow failed his physical exam after being diagnosed with a Grade 3 hamstring strain, which would keep him from participating in the remainder of the season, halting his return. ==References==