in
Darmstadt, the world's oldest operating chemical and pharmaceutical company, as well as one of the largest pharmaceutical companies globally. With its central location in southwestern Germany, the Frankfurt Rhine-Main region has been an important industrial and transport center since industrialization began in the mid-19th century. The region is a major financial center of both Germany and Europe, with the
European Central Bank headquartered in Frankfurt am Main. In 2018, about 7.9% of Germany's gross domestic product (GDP) was generated in the region, as well as over three-fourths of the state of Hesse's GDP. In addition to banking and finance, the
chemical industry has had a long established presence in the metropolitan region, with the
Industriepark Höchst (Höchst Industrial Park) in the southwestern outskirts of Frankfurt am Main being one of the largest industrial parks in Germany and host to over 90 chemical, pharmaceutical and healthcare firms. Other such firms like
Boehringer Ingelheim,
Merck Group,
Biontech,
Fresenius and
Fresenius Medical Care are spread all over the Rhine-Main area. The automobile, construction, and real estate sectors also contribute to a significant sector of the regional economy, with the latter two accounting for 18% of the GDP. Darmstadt and Wiesbaden are the site of headquarters and major offices for insurance firms. serves as a major gateway and logistical hub for the area and is Germany's busiest airport. Geographically situated in the middle of the European continent, Frankfurt Rhine-Main is one of the largest logistics hubs in the world, with major connections provided by
Frankfurt Airport, Germany's and one of the world's busiest air hubs, and an extensive road and rail system. The
Frankfurter Kreuz and
Frankfurt am Main Hauptbahnhof are among the busiest road and rail interchanges in Europe respectively. Other major rail stations include
Mainz,
Frankfurt Süd, and
Frankfurt Airport. ==Transport==