De Barra's role during the republican rebellion in Ireland, Easter 1916, was to act as a courier carrying messages and ammunition between the main headquarters in the
General Post Office and other posts. She did her role well during the Rising and gained the respect of many Irish Republicans. On the orders of one of the principal leaders of the rising -
Seán Mac Diarmada, de Barra (Price) and fellow Cumann na mBan member
Bríd Dixon were promoted in the field and treated as Officers. de Barra later admitted that the job was stressful. She was the person sent to fetch a priest for the dying and wounded soldiers on the Thursday. By the Friday evening de Barra was in the GPO and was with the group evacuated with
Louise Gavan Duffy. Once they reached the hospital on Jervis Street she parted company from Duffy and headed to Jacob's factory to see how the rebels were getting on there. She was also arrested and held in Broadstone Station but quickly released. ==After the Rising==