Frema lectured at the Department of Home Sciences of the
University of Ghana from 1976 to 1982. She eventually became the Head of Department. She has also worked with the United Nations in the Women in Fisheries project in various capacities in
Uganda,
Ethiopia,
Congo and
Namibia. Frema in 2005 – 2008 worked under the government of President
John Agyekum Kufuor as the Deputy Minister for Manpower, Youth and Employment. Between 2005 and 2013, Frema served as Member of Parliament for
Ayawaso West Wuogon. On Friday, July 7th, 2023, The
Valley View University bestowed an honorary Doctorate Degree upon Akosua Frema Osei-Opare, the Chief of Staff, in recognition of her exceptional accomplishments and unmatched contributions to the advancement of Ghana. The citation highlighted, "On the basis of these achievements and contributions that you, your honour, had made to the development of Ghana and the general progress of humanity, Valley View University hereby acknowledges these achievements and hereby confer on you the Degree of Doctor Science (Honours Causa) this day, Friday, July 7, 2023." On Sunday, March 3, 2024, at the
Jubilee House, Akosua Frema Osei Opare, Chief of Staff of the Republic of
Ghana, threw an exclusive event for representatives of the Black Queens. == Political career ==