Typical freshwater species (such as many river mussel species in the family
Unionidae) have a
range which may consist of a series of adjacent river systems, a series of adjacent tributaries, or part of a single large river system. Large rivers and small tributary creeks typically share few species, and distribution patterns suggest large lowland rivers represent substantial barriers to the dispersal of species adapted to small upland streams.
Endemism is common in some families, and species may be endemic to a single creek or spring. In contrast, some of the tiny
pill clams have a nearly worldwide distribution (Burch, 1972) ==Ecological and anatomical challenges==