In 1932, Pope
Pius XI appointed Reyes as Bishop of Cebu. He received his episcopal consecration in the Cathedral of Jaro, on October 11, 1932, from the
Apostolic Delegate, Archbishop
Guglielmo Piani, with Bishop McClosky and
Lipa Bishop
Alfredo Verzosa, as co-consecrators. Two days after, he was installed in Cebu. On April 28, 1934, after more than three centuries, the Diocese of Cebu was elevated by
Pope Pius XI into an
archdiocese, with Reyes as the first archbishop. It was in this context that he renovated the
Cebu Cathedral, which had been bombed during
World War II. On August 25, 1949, he was appointed by
Pope Pius XII as coadjutor to Manila Archbishop
Michael J. O'Doherty with right of succession. On the death of the Archbishop on September 29, 1949, he took over the archiepiscopal See of Manila, being its first Filipino archbishop. As archbishop of Manila, he oversaw the construction of the new campus of
San Carlos Seminary in Makati in 1951. A Catholic center he wished to build when he became archbishop of Manila was built by his successor, the Pope Pius XII Catholic Center, on U.N. Avenue in
Manila. ==Death and Legacy==