Although the Galena River is mostly in Indiana, the entire Galena/Galien watershed consists of , of which one-quarter, , are in Indiana, the remainder being in Berrien County, Michigan. In Indiana, the watershed remains relatively undeveloped; the two principal land uses are forest and agriculture. There are no large urbanized areas in the watershed. In comparison to other watersheds along the Lake Michigan coastal area, the Galena River has not been significantly impacted by human influence, Within Indiana, the Galena River watershed is located within the physiographic unit known as the Valparaiso Morainal Area. The
Valparaiso Moraine, located south of the
Lacustrine Plain, is an arc-shaped moraine complex that parallels the southern shore of Lake Michigan. The moraine divides LaPorte County into northern and southern drainage areas. The area north drains into Lake Michigan; south of the moraine water drains to the
Kankakee River. Numerous
kettle lakes sit on the moraine. Land use in the watershed is principally forest and agriculture. ==Ecology==