Narlikar researches the fundamental processes that underpin
epigenetic mechanisms. In particular, she is interested in how nanoscale molecular motors make use of chemical energy to mechanically disrupt the genome. Beyond molecular motors, Narlikar studies the receptor-like behaviour of nucleosomes. Prior to the work of Narlikar, it was assumed that nucleosomes acted as stable and rigid docking sites for DNA. These nucleosomes change shape to regulate access to the underlying
DNA. She uncovered the role of HP1a proteins in sequestering part of the genome (
heterochromatin) and the role of liquid-liquid phase separation in nucleus reorganisation. In 2014, Narlikar started to teach a summer course on Chromatin, Epigenetics, and Gene Expression at the
Cold Spring Harbor Laboratory. == Awards and honours ==