or deforestation causing
habitat fragmentation. If they are specific in their diets, this can also lead to habitat isolation and reproductive constraints, leading to greater population bottleneck, and decrease in genetic viability.
Genetic viability of particular wolf populations A small highly
inbred population of gray wolves (
Canis lupus) residing in
Isle Royale National Park, Michigan, USA has been undergoing population decline and is nearing extinction. These gray wolves have been experiencing severe
inbreeding depression primarily determined by the
homozygous expression of strongly deleterious recessive
mutations leading to decreased genetic viability. Reduced genetic viability due to severe inbreeding was expressed as reduced reproduction and survival as well as specific defects such as malformed vertebrae, probable cataracts, syndactyly, an unusual "rope tail," and anomalous fur phenotypes. A separate inbred Scandinavian population of gray wolves (
Canis lupus), also suffering from loss of genetic viability, is experiencing inbreeding depression likely due to the homozygous expression of deleterious recessive mutations. == Population conservation ==