George C. Payne was an American tropical physician and director for the International Health Board of the Rockefeller Foundation for Mexico and Trinidad in the 1920s. He also worked as a physician for the state health board in Virginia in 1923. As part of the Rockefeller Foundation’s International Health Board activities, Payne participated in large-scale anti-hookworm campaigns that combined epidemiological surveys, treatment programs, and sanitation measures in collaboration with local authorities in the Caribbean and Latin America. He investigated hookworm disease between 1921 and 1934, conducting epidemiological studies of infected communities and long-term evaluations of areas influenced by hookworm control measures.