Sellers married Rachel Brooks Parrish on March 6, 1833. They had five children and adopted an orphaned daughter of his cousin. Parrish died on September 14, 1860, in Illinois and was survived by only one son out of their five children. He had a deep interest in
archaeology. He wrote several articles on the relics of the
mound builders of Illinois — one published by
Smithsonian Institution was on the aborigines' method of making earthenware salt pans. He also wrote detailed articles on how the local American Indians made
arrowheads and stone age tools. He personally became so skilled at making arrowheads that some specimens of his craft were on display at the
National Museum of the American Indian, Washington, D.C. He also had a substantial collection of
pottery and implements of the prehistoric tribes of the Ohio valley. His grandfather Charles Wilson Peale and his uncles
Rembrandt Peale and
Raphaelle Peale were notable artists of the time. In Sellers's opinion, Raphaelle was the most talented of Charles's artist children. Sellers also had recognized artistic talent;
Thomas Sully had urged him at an early age to become a
portraitist and offered to teach him, but he was more interested in pursuing a vocational career. Nonetheless, he indulged his taste for arts and the society of artists throughout his life. He patented different art inventions from time to time and coordinated "one of the earliest social organizations of artists in Philadelphia", according to Cope (1904). ==
The Gilded Age: A Tale of Today==