Space Ghost Lowe did occasional voice-over work for
TBS throughout the late 1980s and early 1990s, as well as occasional voice-overs for Cartoon Network in the mid 1990s. Lowe's career as a voice actor officially began in 1994 with the premiere of
Space Ghost Coast to Coast, in which he starred as the lead role of
Space Ghost.
Space Ghost Coast to Coast finished a ten-year run of new episodes on Cartoon Network/Adult Swim in 2004, and was revived on
GameTap for two seasons during 2006–2008 for an additional 16 episodes. Lowe performed Space Ghost's voice more than any other role in his acting career, and he portrayed the character more often than any other actor (
Gary Owens being second and
Andy Merrill the third). In addition to
Space Ghost Coast to Coast and its spin-off program
Cartoon Planet, he made appearances as Space Ghost in
Aqua Teen Hunger Force Colon Movie Film for Theaters,
The Brak Show (he was also a series regular, providing the voice for Dad),
Robot Chicken (among various other characters),
Perfect Hair Forever, and other
Adult Swim series. As Space Ghost, Lowe served as the voice of the Cartoon Network's merchandise phone sales line. Lowe performed live and in costume as Space Ghost during the
Aqua Teen Hunger Force Colon Movie Film for Theaters premiere
webcast for
Adult Swim; it can also be found among the extras of the
Aqua Teen Hunger Force Volume Five DVD set. Lowe reprised his role as Space Ghost in the 2011 game
Cartoon Network: Punch Time Explosion (where Space Ghost is the announcer), but did not voice the character in the 2012 revival of
Cartoon Planet.
Other roles Lowe recorded dialog for the film
Radioland Murders, produced by
George Lucas, but his scenes were cut from the final film. Lowe appeared as Dick, the chief executive officer of the fictional Bebop Cola company, in a live-action segment of the
Sealab 2021 episode "All That Jazz". He also played the recurring character of himself on
Aqua Teen Hunger Force, in which he had a different occupation in every episode; he also played the character "Jet Chicken" on the show. Lowe also provides voices on multiple episodes of
Robot Chicken, with his most well-known recurring role being the perverted Unicorn. Lowe is a recurring character in
Artix Entertainment games. Lowe made a special guest voice appearance in the online games
AdventureQuest Worlds and
Mech Quest for their Friday the 13th events in August 2010, in which he takes the role of a park ranger who tells stories around campfires – but is eventually revealed to be a spirit that feeds on fear. Lowe further appears in
Mech Quest as GLaDERP, a parody of
GLaDOS from
Portal. Lowe narrated the
AQW second-year birthday event, and also made a special guest voice appearance in the online game
DragonFable for the Falconreach Idle event in November 2010; he voiced himself in a panel of three judges for the event. In December 2010, as part of the game's one-year anniversary event, George Lowe, as himself, became a fightable
NPC in
EpicDuel, Artix Entertainment's PvP MMO. Lowe did voice-over work for various media outlets and other companies. For example,
San Francisco Bay Area active rock station
KSAN uses Lowe's voice in
station identification spots. He also did voiceovers for
Cleveland rock station
WNCX, the
Fox,
FX, and
FXX television networks, and commercials for
Dunkin' Donuts and
Capital One. George Lowe also played a small role in the animated series
Beetlejuice as Super Ego in the episode "
Super Zeroes". Lowe was among the event guests in the
MMORPG AdventureQuest Worlds. He did announcing work for
Sponsors vs. Freeloaders from the second episode forward, and was the announcer for
The B.S. of A. with Brian Sack. Lowe can be heard introducing and closing each episode of Adult Swim Central Central Presents Colon Adult Swim Swimcast Intended for the Internet (the Swimcast). ==Illness and death==