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George Mitchell (trade unionist) (1827–1901), leader of the National Agricultural Labourers' Union in England •
George Mitchell (priest) (1835–?), missionary priest of the Anglican Church serving in the South Africa •
George Arthur Mitchell (1860–1948), Scottish businessman •
George W. Mitchell (1904–1997), American economist, former Federal Reserve Vice Chairman •
George Hoole Mitchell (1902–1976), British geologist •
George Francis Mitchell (1912–1997), Irish geologist and naturalist •
George Allan Mitchell (1911–1944), English recipient of the Victoria Cross •
George Mitchell School, school in London named after George Allan Mitchell V.C. •
George P. Mitchell (1919–2013), American businessman, real estate developer, and pioneer of shale gas technology •
George Mitchell (criminal) (), Irish criminal nicknamed "The Penguin"