In 1917 he moved to Sydney and set up his own agency. In 1920 he met Norman Catts who was a big name in the fledgling advertising industry in Sydney, being elected president of the Second Advertising Convention of Australia in 1920. The two merged their interests into the Catts-Patterson agency which was Australia's largest agency throughout the 1920s. Clients included Palmolive,
Ford and later
Dunlop Rubber,
Berlei,
Gillette and
Pepsodent. Catts and Patterson split in 1934. Patterson bought a small business named Griffin, Shave & Russell and formed the George Patterson agency. Patterson was known for an ability to get close to his clients' businesses being a director of clients Gillette,
Colgate-Palmolive and later
Peek Frean and Hartford Fire Insurance. During the 1930s Patterson researched the latest international trends in radio advertising during his extensive travels. In 1938 the agency established an innovative radio production outfit – the Colgate-Palmolive Radio Unit – which produced branded content. During
World War II it created campaigns for government bonds and troop entertainment programs featuring stars of the day such as
Roy Rene,
Jack Davey and
Bob Dyer. Patterson worked tirelessly for the
Australian Red Cross Society, directing their publicity functions from 1940 onwards. He was a member of the Red Cross's New South Wales divisional council (1940–68), and on the national council (1941–68). He chaired the Red Cross's rehabilitation (social service) and was made an honorary life member of the national council in 1961. During World War II Patterson was an air-raid warden at
Bellevue Hill, his home suburb in Sydney. He maintained a savings plan for agency staff who were away on active duty. ==Retirement==