SR 376 begins at an
intersection with
SR 31 in
Clyattville, within
Lowndes County. The highway travels to the southeast and curves to the east. Later, it curves back to the southeast and makes a longer curve to the east-northeast. It has an
interchange with
Interstate 75 (I-75). The route continues to the east-northeast and enters the western part of
Lake Park, where it intersects
US 41/
SR 7 (West Marion Avenue). The three highways travel
concurrently into the main part of town, where SR 376 splits off to a generally east-northeastern direction. It travels through
rural areas of
Echols County, and crosses over the
Alapahoochee River, until it meets its eastern terminus, an intersection with
SR 135 west of
Statenville. ==History==