SR 80 begins at an intersection with
US 78/
SR 10/
SR 17, southeast of
Washington in Wilkes County. It heads south-southeast and crosses over the
Little River at the
meeting point of Wilkes, Warren, and McDuffie counties. For approximately , the highway runs along the Warren–McDuffie county line, then enters Warren County proper. In
Cedar Rock, it intersects the former western terminus of
SR 223. Almost immediately is an
interchange with
Interstate 20 (I-20). Then, it heads southwest, passing through
Camak, and heads toward
Warrenton. Just before entering the city limits, it intersects the northern terminus of
SR 80 Alternate (VFW Road). In town it has an intersection with
US 278/
SR 12/SR 80 Alternate. This intersection also marks the eastern terminus of
US 278 Bypass/
SR 12 Bypass. US 278 Bypass/SR 12 Bypass/SR 80 begin a
concurrency around the southeast edge of town. Approximately later, SR 80 splits off to the southeast. It intersects the western terminus of
SR 17 Connector (Purvis School Road) on the Warren–Glascock county line. It passes through
rural areas of Glascock County, without any major intersections, and crosses into Jefferson County. SR 80 continues to the southeast, intersecting
SR 296, before meeting
SR 17. The two highways head concurrently into
Wrens. At the intersection with
SR 102, which heads west-northwest, SR 80 departs to the east on Stapleton Highway. About two blocks later is
US 1/
US 221/
SR 4/
SR 88/
SR 540 (Main Street). Here, SR 80/SR 88 head to the east. At Waynesboro Road, SR 80 splits off to the south-southeast. It travels through rural areas of the county and passes into Burke County. The route curves to the east and meets
SR 305. It curves to the southeast before heading east-southeast. The highway begins a concurrency with
SR 24 just before entering
Waynesboro. About later,
SR 56. At the intersection with
US 25/
SR 121 (Liberty Street), SR 24 turns right, while SR 56/SR 80 continue through town. They meet
US 25 Bypass/
SR 121 Bypass. The two highways continue to the northeast, and curve to the north-northeast, before splitting. SR 80 heads northeast and intersects
SR 23 in the
unincorporated community of
Shell Bluff. The highway continues to the northeast, until it meets its eastern terminus, an intersection with
SR 56 Spur, northeast of Shell Bluff. ==Major intersections==