Georgy Gause

Gause was born December 27, 1910, in Moscow, Russia to parents Frants Gustavovich Gause, a professor of architecture at Moscow State University, and Galina Gause, an industrial worker at an automotive steel plant. As a boy and into his teenage years, Gause and his extended family took summer vacations to the Caucasus Mountains in southern Russia for months at a time. Although his family was not wealthy, they were allowed these respites because his father, being a government architect, helped to build many structures at the university. It was during these trips to the Caucasus Mountains that Gause grew fond of nature, often chronicling the lives and behavior of several organisms including the Siberian grasshopper (Aeropus sibiricus). He became interested in zoology, particularly the animal variability. ==At university==

In 1927 he was admitted to the Biological Division of the Faculty of Physics and Mathematics at Moscow University. The Russian university system requires a faculty advisor for all undergraduate and graduate students. His chosen advisor for his undergraduate career was professor Vladimir Alpatov, who worked at the Zoological Museum of Moscow University. Alpatov, in the mid-1920s, was very impressed by the work of Raymond Pearl, a U.S. demographer who became well-known through his advocacy of the logistic curve. Alpatov brings back a fascination for American science that is very influential on Gause. Gause argued that field work, with too many variables, could never adequately explain this relationship and only in the simplified laboratory environment, where variables could be controlled, would it be possible to determine precisely how a specific ecological factor influences a population. Eager to pursue this mechanistic direction of study and influenced by his advisor, Gause contacted Pearl to see if the American would take on another Russian student. He applied for a fellowship through the Rockefeller Foundation but was denied, perhaps because he was only 22 years old. He then published a monograph The Struggle for Existence in 1934 to improve his chances but he was still denied. The monograph had several editions, and it was also translated in French and Japanese languages. During Alpatov's stay in the US, Gause was supervised by Evgenii Smirnov. Interested in the application of statistics in biosystematics, Smirnov promoted these methods to Gause. In that period Gause was investigating the distribution of Orthoptera in the North Caucasus, quantitatively estimating ecoplastisity of species. Gause earned his BSc at Moscow State University in 1931, and was employed in Alpatov's laboratory at the Zoological Institute of Moscow University. He earned his DBiolSc in 1936 for the series of works published in 1930-1934 and compiled as a dissertation titled Studies on the dynamics of mixed populations. One of the opponents was Vladimir Vernadsky. ==The struggle for existence by competitive exclusion==

In 1932, Gause published what has become known as the competitive exclusion principle, based on experimental work done with mixed cultures of both yeast and Paramecium species. Aphoristically, it was formulated as "One niche — one species". The principle asserts that no two species with similar ecological niches can coexist in a stable equilibrium, meaning that when two species compete for exactly the same requirements, one will be slightly more efficient than the other and will reproduce at a higher rate as a result. The fate of the less efficient species is local extinction. In another series of experiments with the infusorians Paramecium as prey and Didinium as a predator, imitating periodical migrations, he obtained nearly ideally sinusoidal fluctuations of the abundances in this model, previously modeled only theoretically. It appeared in English as an abridged version in USA, and finally published in Russian only in 1984. One of the first acceptances of the advantages of polycultures was also obtained by Gause on Paramecium. He studied ecologically similar species of infusorians. Keeping them as monocultures he obtained higher abundances of individual species than in polyculture. Meanwhile, significantly higher was the overall abundance of the polyculture. In 1940 Gause prepares a monograph Ecology and some problems of the origin of species. The original manuscript in Russian was not published due to start of the World War II in the Soviet Union. It appeared in as an abridged version in USA, and finally published in Russian only in 1984. ==Protoplasm asymmetry==

In the 1930s Gause conducted a series of studies, dedicated to the protoplasm asymmetry. These works raised interest among biogeochemists, including V.V. Vernadsky. ==The search for new antibiotics==

From 1939 Gause began studies of antibiotics. Seemed like a sudden change in research topic, but this was a development of his interests in the struggle for survival, and antibiotic activity was a mean. Later he focuses his research on practical applications for his new principle and turns to microbiology and medical science. Working with a strain of Bacillus brevis, he noticed an inhibition on the growth of Staphylococcus aureus when the two were in mixed culture. The inhibition of S. aureus was caused by a metabolite produced by B. brevis. Gause isolated this product and named it Gramicidin S. The antibiotic went into mass production during World War II and saved many lives. For his part in its development, Gause was awarded the Stalin Prize and named director of the Institute for New Antibiotics in Moscow in 1946. As director, Gause helped to design and manufacture many novel antibiotics of which a few had anti-tumor capacities. Due to such abrupt change in scientific interests many biologists failed to unite the evolutionist and the microbiologist in one personality. ==See also==