Mulder was born in
Utrecht and earned a medical degree from
Utrecht University. He became a
reader of chemistry in
Rotterdam and in 1840 he was appointed
professor at
Utrecht University. Mulder "was the first to propose a theory concerning the causes of the differences between
albumin,
casein, and
fibrin, and other substances more or less similar to them in physical properties and in their chemical behavior when exposed to reagents. Analyses of these substances showed that their percentage contribution with respect to carbon, hydrogen, nitrogen and oxygen were so similar as to suggest that they contain one common radical." This radical, a
macromolecule, had formula C20 H31 N5 O12 , and was known as
protein. The variations in albuminous substances were attributed to peripheral bonds of protein to sulfur and/or phosphorus.
Justus Liebig and his students sought to determine the structure of proteins, but until the methods of
Emil Fischer and
Franz Hofmeister became available, the
amino acid decompositions were unknown.
Augustus Voelcker was Mulder's assistant for a year from 1846. In 1850, Mulder was elected a foreign member of the
Royal Swedish Academy of Sciences. He died in
Bennekom. ==References ==