Ghana made its Paralympic Games début at the 2004 Summer Paralympics in Athens, sending three representatives to compete in two sports. Nkegbe Botsyo, in athletics, took part in the men's 100m, 200m and 400m, in the T54 category. Ajara Mohammed entered the women's 800m and the marathon, also in the T54 category. Alfred Adjetey Sowah competed in powerlifting, in the men's up to 52 kg.