Gi alpha subunit

There are four distinct subtypes of alpha subunits in the Gi/o/z/t alpha subunit family that define four families of heterotrimeric G proteins: • Gi proteins: Gi1α, Gi2α, and Gi3α • Go protein: Goα (in mouse there is alternative splicing to generate Go1α and Go2α) • Gz protein: Gzα • Transducins (Gt proteins): Gt1α, Gt2α, Gt3α Giα proteins Gi1α Gi1α is encoded by the gene GNAI1. Gi2α Gi2α is encoded by the gene GNAI2. Gi3α Gi3α is encoded by the gene GNAI3. Goα protein Go1α is encoded by the gene GNAO1. Gzα protein Gzα is encoded by the gene GNAZ. Transducin proteins Gt1α Transducin/Gt1α is encoded by the gene GNAT1. Gt2α Transducin 2/Gt2α is encoded by the gene GNAT2. Gt3α Gustducin/Gt3α is encoded by the gene GNAT3. == Function ==

The general function of Gi/o/z/t is to activate intracellular signaling pathways in response to activation of cell surface G protein-coupled receptors (GPCRs). GPCRs function as part of a three-component system of receptor-transducer-effector. The transducer in this system is a heterotrimeric G protein, composed of three subunits: a Gα protein such as Giα, and a complex of two tightly linked proteins called Gβ and Gγ in a Gβγ complex. Gi and Go proteins are substrates for pertussis toxin, produced by Bordetella pertussis, the infectious agent in whooping cough. Pertussis toxin is an ADP-ribosylase enzyme that adds an ADP-ribose moiety to a particular cysteine residue in Giα and Goα proteins, preventing their coupling to and activation by GPCRs, thus turning off Gi and Go cell signaling pathways. Gz proteins also can link GPCRs to inhibition of adenylyl cyclase, but Gz is distinct from Gi/Go by being insensitive to inhibition by pertussis toxin. Gt proteins function in sensory transduction. The Transducins Gt1 and Gt2 serve to transduce signals from G protein-coupled receptors that receive light during vision. Rhodopsin in dim light night vision in retinal rod cells couples to Gt1, and color photopsins in color vision in retinal cone cells couple to Gt2, respectively. Gt3/Gustducin subunits transduce signals in the sense of taste (gustation) in taste buds by coupling to G protein-coupled receptors activated by sweet or bitter substances. == Receptors ==

The following G protein-coupled receptors couple to Gi/o subunits: • 5-HT1 and 5-HT5 serotonergic receptors • Acetylcholine M2 & M4 receptors • Adenosine A1 & A3 receptors • Adrenergic α2A, α2B, & α2C receptors • Apelin receptors • Calcium-sensing receptor • Cannabinoid receptors (CB1 and CB2) • Chemokine CXCR4 receptor • Dopamine D2, D3 and D4 receptors • GABAB receptor • Glutamate mGluR2, mGluR3, mGluR4, mGluR6, mGluR7, & mGluR8 receptors • Histamine H3 & H4 receptors • Melatonin MT1, MT2, & MT3 receptors • Hydroxycarboxylic acid receptors: HCA1, HCA2, & HCA3 • Opioid δ, κ, μ, & nociceptin receptors • Prostaglandin EP1, EP3, FP, & TP receptors • Short chain fatty acid receptors: FFAR2 & FFAR3 • Somatostatin sst1, sst2, sst3, sst4 & sst5 receptors • Trace amine-associated receptor 8 == See also ==