Best known by his nickname
Picchio, during his club career, De Sisti played for his hometown club
A.S. Roma on two occasions (1960–65, 1974–79), and
ACF Fiorentina (1965–74), winning several domestic and international titles with both clubs. He made his debut in
Serie A with Roma in a 2–1 away defeat to
Udinese, on 12 February 1961, in which he observed the team's star player and mentor
Juan Alberto Schiaffino during his first spell at the club. He enjoyed his most successful period with Fiorentina, which included a league title in
1969, the club's second overall, before returning to Roma in 1974. He won the
Coppa Italia with both clubs, in 1964 and 1966. ==International career==