Henderson's research seeks to understand processes in the surface-Earth system. His work has made extensive use of the isotopes created by decay of natural uranium (the
U-series decay chain) to assess the rates and timing of environmental processes. He has also been a pioneer in the use of novel isotope systems, particularly lithium, calcium, cadmium, and barium isotopes to trace environmental processes.
Past Climate: Henderson's work uses the record of past climate captured by the chemistry of sediments and stalagmites to understand processes in the climate system that are hard to understand from present climate alone. Particular advances have been his use of precise marine chronology to help understand the mechanisms of ice-age deglaciation and sea-level change; the chemistry of stalagmites to quantify the response of Asian monsoon rainfall to climate change; and the growth of stalagmites to understand the sensitivity of Siberian permafrost to warming and the presence of sea-ice.
Marine: With Bob Anderson, Henderson chaired the planning group (2004–2006) and subsequent scientific steering committee (2007- 2012) that initiated the marine chemistry programme, GEOTRACES and lead its growth to a successful global programme. He led the group that wrote the 2017 Royal Society report,
Future Ocean Resources. His own oceanic research includes the use of U-series isotopes to assess the rates of marine processes such as circulation and sea-level rise.
CO2 Removal: Henderson was a founding director (2010–2013) of the Oxford Geoengineering programme, and a member of the steering committee for the
NERC Public Dialogue on Geoengineering. In 2017 he chaired the group that wrote the Royal Society and Royal Academy of Engineering report,
Greenhouse Gas Removal. His own research includes assessment of enhanced rock weathering and ocean alkalinity enhancement. ==Awards==