•
Saint Giles, 7th/8th-century Christian hermit saint •
Alfred Giles, several people •
Giles Alington, several people •
Giles Andreae (born 1966), British writer and illustrator •
Giles of Assisi, Aegidius of Assisi, 13th-century companion of St. Francis of Assisi •
Giles of Rome, 13th-century archbishop •
Giles Barnes (born 1988), English footballer •
Giles Leonard Barrett ( 1744–1809), English actor •
Giles Blunt (born 1952), Canadian novelist and screenwriter •
Giles Brindley (born 1926), British physiologist, musicologist and composer •
Giles Brook (c. 1553–1614), English politician •
Giles Brydges, several people •
Giles Chichester (born 1946), British Conservative Party politician •
Giles Clark, English conservationist and TV presenter •
Giles Clarke (born 1953), British businessman then cricket administrator •
Giles Coke (born 1986), English professional footballer and coach •
Giles Cooper, several people •
Giles Coren (born 1969), British journalist •
Giles Corey (1621–1692), victim of the Salem witch trials •
Giles Daubeney, several people •
Giles Deacon (born 1969), British fashion designer •
Giles Duley (born 1971), English photographer, chef, writer, CEO and presenter •
Giles Fletcher, the Elder ( 1548–1611), English poet, politician, and diplomat •
Giles Fraser (born 1964), English Anglican priest and broadcaster •
Giles Goddard (born 1962), British Church of England priest •
Giles Goddard (video game programmer) (born 1971), English video game programmer •
Giles Gordon (1940–2003), Scottish literary agent and writer •
Giles B. Harber (1849–1925), American United States Navy admiral •
Giles Henderson (born 1942), Master of Pembroke College, Oxford •
Giles W. Hotchkiss (1815–1878), American attorney and politician •
Giles Hussey (painter) (1710–1788), English painter •
Giles Hussey (tennis) (born 1997), British tennis player •
Giles Jackson (born 2001), American football player •
Giles Beecher Jackson (1853–1924), African-American lawyer, newspaper publisher, entrepreneur, and civil rights activist •
Giles Kristian (born 1975), British author •
Giles Lamb, British music composer and sound designer •
Giles Mackay (born 1961/1962), British businessman and property investor •
Giles Martin (born 1969), English record producer and songwriter •
Giles Matthey (born 1987), British actor •
Giles Milton (born 1966), British writer and historian •
Giles Mompesson ( 1583 – 1663), English politician •
Giles Pellerin (1906–1998), American businessman •
Giles Portman, British diplomat •
Giles Radice, Baron Radice (1936–2022), British politician •
Giles Rich (1904–1999), American judge •
Giles Rooke (1743–1808), English judge •
Giles Gilbert Scott (1880–1960), British architect •
Giles Scott-Smith, Dutch-British political researcher •
Giles Smith, several people •
Giles Strangways (died 1546), MP •
Giles Strangways (1528–1562), MP •
Giles E. Strangways (1819–1906), pioneer settler of South Australia •
Giles Terera, British actor and singer •
Giles Ji Ungpakorn (born 1953), Thai academic and Marxist political activist •
Giles Watling (born 1953), British actor and politician •
Giles Worsley (1961–2006), English architectural historian •
Giles Yeo, American-British biologist ==Fictional characters==