Early career with Reggina and loan to Cuneo Di Lorenzo began his career with the
Reggina youth system in 2009. On 29 May 2011, he made his professional debut for the senior side in a
Serie B match at
Sassuolo. He spent the
2012–13 season on loan with
Lega Pro Prima Divisione side
Cuneo, collecting 27 appearances and drawing attention due to his promising performances.
Matera and Empoli Between 2015 and 2017, Di Lorenzo played for
Matera, collecting 58 appearances and scoring 3 goals. After helping the side achieve promotion to
Serie A, he made his debut in the Italian top flight on 19 August 2018 against
Cagliari; in the return fixture against the same opponent, he scored his first Serie A goal. During his first year at Napoli, Di Lorenzo became a first team starter, taking them to seventh in the
Serie A and helping them secure a win against
Juventus in the
Coppa Italia Final. Napoli also reached the
Round of 16, in the
Champions League, with Di Lorenzo getting 2 assists and playing every game. In his second year at the club, he helped guide the team into the
Round of 32, at the
Europa League, however, they lost to
Granada, 3–2 on aggregate. Napoli also finished fifth in the league. Di Lorenzo has scored 7 goals for Napoli, in the League and Domestic Cups. On 15 July 2020, the
right-back was linked to a move with
Manchester United, but instead opted to sign a 5 year deal with Napoli, seeing him remain at the club until 2026. On 14 July 2022, Di Lorenzo was named the new Napoli club captain following the departures of
Lorenzo Insigne and
Kalidou Koulibaly. On 4 October, he scored his first Champions League goal in a 6–1 away win over
Ajax during the
2022–23 season. ==International career==