Upon Pope Innocent's election in September 1644, Panciroli was appointed
Cardinal Secretary of State, which duties he shared with the Pope's
Cardinal-Nephew Camillo Francesco Maria Pamphili until in January 1647 Pamphili resigned his cardinalate to marry
Olimpia Aldobrandini. The resignation increased Panciroli's role, which enjoyed an authority in the Curia unusual for a minister not a blood relative of the Pope, even for a secretary of state, a position still far from taking on the importance that would later have. At the same time he had to contend with the significant influence Donna Olimpia held with her brother-in-law, the pope. This situation periodically impeded the efficient operation of the curia. When Innocent X asked the Secretary of State for a recommendation regarding a replacement for his woefully incompetent Cardinal-nephew, Francesco Maidalchini. Pancirolo suggested his secretary,
Camillo Astalli, a distant relative by marriage to Olympia. Although continuing to enjoy the unconditional esteem of the pope, this raised the ire of the Pamphili family and their associates. Constant attacks combined with declining health contributed to a progressive loss of authority in the Curia. Panciroli died on 3 September 1651 at the
Quirinal Palace in Rome. Upon Panciroli's death, the position was filled by Fabio
Chigi who was later elected to the papal throne as
Pope Alexander VII. ==References==