Medical practice and diplomatic service After graduation, Minadoi practiced medicine in Rovigo, occasionally spending time in
Venice, where three of his brothers resided. In 1578,
Teodoro Balbi, newly appointed as the Venetian consul in
Syria, invited Minadoi to accompany him to
Aleppo as his personal physician. Aleppo was then a major commercial hub for trade with
Safavids, allowing Minadoi to build a prestigious clientele that included Muslim patients. These connections inspired him to document the war that had broken out in 1578 between
Murad III and
Mohammad Khodabanda. Minadoi returned to Venice by April 1583. Shortly after his return, he was hired by the
Gonzaga family to treat
Duke Guglielmo, who suffered from
arthritis and
rickets—hereditary ailments in the family. On May 6, 1583, Minadoi arrived in
Mantua, but his tenure there was unsuccessful. Despite being responsible for providing consistent care to the Duke, he was lodged in countryside. By February 1584, he requested to be relieved of his position and returned to Venice three months later. In late 1584, Minadoi accepted a second appointment in Syria, serving under consul
Giovanni Michiel, who had previously been the
Superintendent of Health. However, in a letter dated March 31, 1585, Minadoi expressed his dissatisfaction with being in "odious and hostile places due to their remoteness, the barbarism of the inhabitants, and the dangers." His acceptance of this role may have been influenced by a lack of better professional opportunities and possible economic interests, as his brother
Pietro Maria was engaged in trade with the
Levant. in September 1586, Minadoi left Ottoman Empire and by December had returned to Venice, traveling via the
Peloponnese, as evidenced by his literary references to herbs and medicines he encountered in that region.
Later career and academic life On April 26, 1587, Minadoi married Lucia Cezza di Bartolomeo in Rovigo, connecting himself to one of the city's wealthiest and most influential families. The marriage remained childless. That same year, he traveled to
Rome, where in the summer he personally delivered his "
Historia" to
Sixtus V.
History of the War between Turks and Persians () was published in Rome in 1587, with a new edition in Venice in 1588. A significant translation into Spanish was done in 1598 by
Antonio de Herrera. The work stands as one of the few European accounts of the Persian world from this period, which explains its success and numerous editions and translations. Upon returning to Rovigo, Minadoi joined the
Accademia dei Concordi, pursuing his interest in literature. In July 1589, on his brother Annibale's recommendation, Minadoi was hired by city of
Udine as a physician, with a considerable annual salary of 400
ducats. The city's health situation was persistently difficult due to its proximity to the border and frequent conflicts with the Turks in
Bosnia. Minadoi remained in Udine for nearly six years, until June 20, 1595, when he unexpectedly resigned. The reasons for this decision are unclear, especially since the city had granted his requested salary increase and inducted him into the noble order. Minadoi retreated to Venice, where he reconnected with members of the pro-curial and pro-Spanish patriciate, who secured him a coveted professorship at Padua, possibly the true cause of his prior dissatisfaction. On December 19, 1596, Minadoi assumed a position teaching extraordinary practical medicine at the University of Padua. He was well received by students, particularly those of German nationality (which earned him appointment as a
Count Palatine on September 19, 1607). His academic career progressed steadily: in 1602, after being inducted into the local
Accademia dei Ricovrati, on January 13 he was promoted to teaching practical medicine in the second position. He reached the first position on December 7, 1612, with a salary of 600
florins, a position he maintained until his death. Minadoi was named a
Knight of St. Mark after delivering a speech in August 1612 for the new Doge
Marcantonio Memmo. In January 1615, he traveled to
Florence at the invitation of Grand Duke
Cosimo II de' Medici. He returned to the Medici court three months later but suddenly fell ill with malignant fever and died in Florence on May 29, 1615. He was buried in the
Church of Saints Michael and Cajetan. == Medical philosophy and works ==