He was born on December 10, 1671, in
Rome, the son of Filippo Colonna, Lord of Sonnino, and his wife Clelia Cesarini. As a teenager, he was married to the great heiress Giovanna van den Eynde. Through his marriage to her, he acquired the title of Marquess of Castelnuovo, the
Palazzo Zevallos Stigliano, a huge art collection, and the greater part of the van den Eynde's fortune, all of which contributed to boost his position. In 1690, the king of Naples chose him as his ambassador to the Holy See for the traditional presentation of the
chinea, the symbolic annual tribute paid by the king of Naples to the pontiff.
King Philip V of Spain, sovereign of the kingdom of Naples, granted him the
Grandeza de España in 1715. He died in Naples on April 11, 1732. ==Marriage and progeny==