Manfredi worked in a law office beginning in 1846. Over the next few years he became interested in politics and expressed his views about democratic philosophies in the newspaper
Il Tribuno del popolo (English:
Tribute of the People) and in pamphlets. He also wrote about
anti-clericalism and
Jacobinism. During the summer of 1859, he held a number of political offices, including Member of the
Provisional Government of Piacenza, administrator of the province of Parma, a Member of the
Assembly of People's Representatives in Parma, and Provisional Governor of Parma and Piacenza.
See also Kingdom of Italy (formed in 1861). In 1862, he became Deputy Attorney General in the
Perugia Court of Appeals. Three years later, he was Advocate General in Perugia. He was also made Attorney General of
Catania in 1868, and then served in that role in
Bologna in 1869, in
Rome in 1876. He was also the first president of the Court of Appeal of
Ancona in 1876. On 20 November 1876, he took the oath as Senator of the kingdom of Italy. From 1881 until 1907, he was the Attorney General at the Supreme Court in
Florence. On 28 December 1907, he was elected vice-president of the upper house of the Senate. From 20 March 1908 until his death, he was the president of the Italian Senate, spanning three terms. Over his career, he was a member of the governing Council of the Order of Lawyers (Italian: ''Consiglio dell'Ordine degli Avvocati
) of Piacenza, the Italian Geographical Society (Società Geografica Italiana
), and the National Committee for the history of the Italian unification (Istituto per la storia del Risorgimento italiano''). ==Personal life and death==