While at Tethys, Notarbartolo di Sciara proposed in 1991 the creation of a large protected area for cetaceans in the north-western Mediterranean, which later became the
Pelagos Sanctuary for Mediterranean Marine Mammals, established by treaty between France, Italy and Monaco. His return to Italy from the U.S. allowed fateful encounters with many of the other champions for marine conservation who would become so instrumental in making the international Pelagos Sanctuary a reality, including Prince Ranier III of Monaco. Key was his membership in and subsequent coordination role in the marine mammal working group of CIESM (the
International Commission for the Scientific Exploration of the Mediterranean Sea). Also critically important was his leadership and support of Tethys, since the Mediterranean cetaceans that are the focus of the NGO also provided the impetus for the establishment of the Pelagos Sanctuary. His involvement with Pelagos Sanctuary continues to this day. As president of ICRAM he spearheaded the promotion of Italy's marine protected area system, based on solid science and monitoring practice. In particular, his efforts were instrumental in the launching of project "Afrodite", whereby the core zones of 15 Italian MPAs were monitored on the basis of standard protocols (e.g.,). Notarbartolo di Sciara has also often worked as a consultant to organisations involved in the conservation and management of the Mediterranean, including the Regional Activity Centre for Specially Protected Areas (RAC/SPA) of
UNEP's Mediterranean Action Plan, and
MedPAN. Notarbartolo di Sciara has also been heavily involved with the conservation of the Red Sea. In particular, he has been a science advisor to HEPCA, the Hurghada Environmental Protection and Conservation Association – the main marine conservation NGO in Egypt. He was also instrumental in creating the highly touted management plan for Samadai MPA, which allowed tourism to co-exist with conservation of spinner dolphins and coral reefs. In 2017 with several colleagues he published a detailed review of cetaceans found in the Red Sea. In 2013, with
Erich Hoyt, he founded the IUCN Joint SSC/WCPA
Marine Mammal Protected Areas Task Force (MMPATF). The Task Force launched in 2016 a programme to identify
Important Marine Mammal Areas (IMMAs) in the world's oceans, seas and inland waters, to support marine mammal and biodiversity conservation. ==Protected species==