In 1924, eager to work with
Oscar Chisini, Biggiogero returned to Milan and was appointed as his assistant and the professor for the descriptive and projective geometry courses at the
Politecnico di Milano. From 1927, she also gave lectures at the Mathematical and Physical Seminary of Milan, which was founded in that year, and taught higher and projective geometry courses at the
University of Milan. She was assigned as the editor of the mathematical entries in the
Enciclopedia Italiana (Italian Encyclopedia, 1933) and reviewed the first sixteen volumes of the work, focusing on the compilations of
Federigo Enriques. In 1939, Biggiogero married
Arnaldo Masotti, a fellow academic, who at the time was the professor of Rational Mechanics in the Faculty of Architecture. She was made chair of Geometry at the
Politecnico in 1948 and retained that post until her retirement in 1969. In addition to lecturing on
descriptive geometry in the mathematics department, she taught
projective geometry to the students in the architectural and engineering departments. Biggiogero's research produced a large body of work on
algebraic geometry, including research on the shapes and bundles of algebraic curves,
tensorial calculations, Hessian singularities of curves and the construction of the triple and quadruple planes. She and Chisini co-published several works together, including two textbooks
Lezioni di geometria descrittiva (Lessons of Descriptive Geometry) published in 1941 and
Esercizi di geometria descrittiva (Exercises of Descriptive Geometry), produced in 1946. As a secondary path, she researched algebraic differentials, studying
transversals, including
Liouville's and
Reiss' theorems, as well as the
invariant theory of
Enrico Bompiani. She was also one of the first scholars in Italy to study
integral geometry. She published works which summarized the results of
Morgan Crofton,
Henri Lebesgue, and
Luis Santaló, presenting new formulas for determining ovals and
ellipses. Also concerned with the history of mathematics, Biggiogero published studies on the geometry of the triangle and the tetrahedron, in conjunction with
Virginio Retali for the
Encyclopedia of Elementary Mathematics. She wrote a biography of
Luca Pacioli and with her husband produced a study on
Maria Gaetana Agnesi and her works. In 1949, she was made a member of the and was also a member of , the Italian Society of Mathematical and Physical Sciences. In 1974,
Clifford Truesdell, editor-in-chief of the
Archive for History of Exact Sciences, dedicated volume 14 to Biggiogero and her husband in recognition of their scholarship. ==Death and legacy==