The institute's research activity is organized into five specialized centers, each developed in collaboration with major international partners. The Energy, Environment and Water Research Center (EEWRC) was created in partnership with the
Massachusetts Institute of Technology (MIT) to address environmental challenges in the Mediterranean. The Science and Technology in Archaeology and Culture Research Center (STARC) works with the
Louvre (C2RMF) to apply advanced imaging and materials science to cultural heritage. In late 2025, the institute inaugurated the A.G. Leventis Archaeological Materials Science Laboratories to further this work. The Computation-based Science and Technology Research Center (CaSToRC) operates in partnership with the
University of Illinois and manages the region’s Tier-1 supercomputing facility. In 2025, CaSToRC researchers, in collaboration with the Climate and Atmosphere Research Center (CARE-C), published the first-ever global maps of ultrafine air pollution using machine learning models. The Science and Technology Driven Policy and Innovation Research Center (STeDI-RC) focuses on sustainability challenges, while CARE-C, a European Center of Excellence established in 2020, leads regional efforts in climate observation and policy development for the EMME region. == Education and Academic Programs ==