In 1935,
David Shakarian, an Armenian-American businessman, opened a small
health food store originally named Lackzoom, in downtown
Pittsburgh. He made US$35 on his first day and was able to open a second store within six months. Despite initial setbacks, such as the
Ohio River flooding into downtown on
St. Patrick's Day that wiped out both stores in 1936, Shakarian persevered and reopened the next year. He later expanded into mail-order sales of health foods, vitamins, and prescription drugs, capitalizing on the growing interest in physical fitness and health consciousness during the 1960s. In the 1960s, the company changed the name of its stores to General Nutrition Centers. Shakarian stepped down as chief executive officer in February 1984 but continued as chairman until his death later that year. GNC was taken private and sold to
Thomas H. Lee Partners a PE investment/management fund in the late 1980s. Thomas Lee ran GNC and took it public prior to selling the company to Royal Dutch Numico and
Numico acquired GNC in 1999; it sold GNC to
Apollo Management in 2003.
Ontario Teachers' Pension Plan and
Ares Management bought GNC in 2007. GNC went public in 2011. In 1990, the company considered relocating but a public/private effort retained GNC headquarters in
Downtown Pittsburgh. In 2018, the Chinese state-owned
Harbin Pharmaceutical Group agreed to acquire an approximately 40% stake in GNC. In September 2020, Senator
Marco Rubio asked the
Committee on Foreign Investment in the United States to examine the proposed acquisition on data protection and national security grounds. In November 2018, the company announced they would be closing up to 900 stores over 3 years. In July 2019, it was announced that they planned to close up to 1,400 company owned retail locations, primarily those located within shopping malls. In June 2020, GNC filed for
Chapter 11 bankruptcy protection due to the negative impact of the COVID-19 Lockdowns and Stay-at-home orders that severely impacted store traffic; resulting in the closure of at least 800 stores. Effective on June 30, 2020, the stock was delisted from the
New York Stock Exchange and shifted to the
OTC Markets Group. In September 2020, the bankruptcy court in Delaware approved the private sale of GNC for $770 million to Harbin Pharmaceutical Group and CITIC Capital. In October 2020,
Harbin Pharmaceutical Group, a Chinese
state-owned pharmaceutical manufacturer, acquired the remainder of the company. In 2021, GNC revealed that Josh Burris will take over as CEO, Nate Frazier as COO and Cam Lawrence as CFO. In 2021, GNC announced a partnership with
Walmart for a selection of GNC specific products. In 2021, GNC launched their Venture Capital Arm under the name GNC Ventures. Led by COO Nate Frazier's investment in Real Eats. Additional investments include supplement brands, POS and OMS software companies. In 2023, COO Nate Frazier unveiled GNC's Flagship in the heart of Pittsburgh. Starting with significant upgrades into the brand's tech stack. A major part of that was updating point-of-sale systems to allow for more in-store ordering, plus functions like loyalty programs. The newest version of the system also allows store associates to be able to sell outside of the store – such as going to a marathon, community event or parking lot tailgate, by utilizing mobile point-of-sale systems. In May 2025, U.S. representative
Pat Harrigan introduced legislation that would prohibit GNC's presence on U.S. military bases due to its Harbin ownership. ==Retail and online stores==